The Convent of the Descalzas Reales is in the palace where Charles I and Isabella of Portugal resided.
Dona Juana, the daughter of Charles V, Holy Roman Emperor, founded this convent of barefoot Franciscan nuns in 1557. The chapel where she is buried contains a sculpture of her at prayer by Pompeyo Leoni. The original structure and many of the decorative elements of this Plateresque palace can still be seen in the convent. There are 17th-century fresco paintings on the staircase and in the Milagro chapel. Particular highlights include the tapestries woven from cartoons by Rubens, representing the Apotheosis of the Eucharist.