The town is located on the Nairobi-Mombasa Highway, in Makueni County, in southeastern Kenya on the map, close to the International border with the Republic of Tanzania.
This location lies approximately 135 kilometres (84 mi), by road, southeast of Machakos, where the provincial headquarters are located. Makindu lies approximately 356 kilometres (221 mi), by road, northwest of the coastal city of Mombasa. The geographic coordinates of Makindu are:2Â° 16' 30.00"S, 37Â° 49' 12.00"E (Latitude:-2.275000; 37.820000).
The settlement was established in the early 20th century, as a base for railway construction workers on the Mombasa-Kampala railway project. The Sikh Temple in Makindu that was built at that time, still bears reminiscence to the railway building days. The temple was a place of worship and social centre for many of the workers from India. The temple is well preserved and is managed as a free lodge for any traveller who knocks on its doors. Makindu is also served by Makindu Airport.