Lake Towuti is a lake in South Sulawesi, Indonesia
, it is the largest lake of the island of Sulawesi and one of the five lakes of the Malili Lake system (the other being Matano, and the small Mahalona, Masapi and Lontoa (Wawantoa)). A river flows from the lake to the Boni Bay. The town Laronda is located on its shore.
Together with the other lakes in the Malili Lake system, Towuti has a large number of endemic fishes (Telmatherinid sail-fin silversides, Glossogobius and Mugilogobius gobies, Nomorhamphus halfbeaks and Oryzias ricefishes), Caridina shrimps, Parathelphusid crabs (Nautilothelphusa, Parathelphusa and Syntripsa) and Tylomelania snails.