Great Marlborough Street runs west to east through the western part of Soho in London. At its western end it joins Regent Street. Streets crossing, or meeting with, Great Marlborough Street are, from west to east, Kingly Street, Argyll Street, Carnaby Street, and Poland Street. At its eastern end, it becomes Noel Street.
Great Marlborough Street is the location of the Tudor wing of Liberty's department store, a few foreign language bookshops, offices and the back entrance to Marks and Spencer's Oxford Street branch. The European Headquarters of Sony Computer Entertainment (PlayStation) and London Studios are also located on the street as was the London College of Music until that institution relocated to Ealing in west London in 1991, being replaced in 1995 by the London College of Beauty Therapy. Great Marlborough Street is shown on the British Monopoly board as "Marlborough Street".