Serrano River is a river located in the Magallanes Region of Chile. Its main tributary is Grey River. The Serrano Glacier is an attraction on the river. The waters of the Serrano River eventually reach Seno Ultima Esperanza.
Several significant elements of prehistory have been found in the region. Notably not far from the southern area of the river's mouth is situated the Cueva del Milodon, a cave where evidence of prehistoric man's habitation has been found, illustrating arrival of humans approximately 10,000 BC.