Jacksonville is located in Cherokee County, Texas, United States. The population was 13,868 at the 2000 census. It is the principal city of the Jacksonville Micropolitan Statistical Area, which includes all of Cherokee County and part of the larger Tyler-Jacksonville Combined Statistical Area. Jacksonville is located in an area of rolling hills in East Texas, north of the county seat, Rusk, and south of Tyler, in Smith County, on U.S. Route 69. The north-south Highway 69 intersects the east-west U.S. Route 79 at the restored Landmark Hotel/Restaurant and the Capitol One Bank in downtown Jacksonville.