Ste. Genevieve is a city in and the county seat of Ste. Genevieve County, Missouri, United States. Founded by French Canadian colonists, it was the first organized European settlement west of the Mississippi River in present-day Missouri. The first to show Ste. Genevieve in the Illinois Country, showed the Kaskaskia natives on the east side of the river, but no Indian village on the west side within 100 miles of Ste. Genevieve. Hunting and war parties did enter the area from the north and west. The region had been relatively abandoned by 1500, llkely due to environmental exhaustion, after the peak of Mississippian-culture civilization at Cahokia.