Ste. Anne de Détroit, founded July 26, 1701, is the second oldest continuously operating Roman Catholic parish in the United States. The current Gothic Revival cathedral styled church, built in 1886, is located at 1000 Ste. Anne St. in Detroit, Michigan near the Richard-Hubbard neighborhood area, the Ambassador Bridge, and the Michigan Central Station.
Historically, the parish community has occupied eight different buildings. It was listed on the National Register of Historic Places in 1976. The main entry to the Church faces a grand tree-lined, brick paved plaza. The present parish is largely Hispanic.