Saint Louis Roman Catholic Church is located at 35 Edward Street, Buffalo, New York.The Church holds the title of "Mother Church of the Roman Catholic Diocese of Buffalo". The Gothic-styled church is located on the site of the first Roman Catholic church ever built in Buffalo.
The church is laid out in a Latin-cross floor plan and features a 245 ft octagonal Medina sandstone steeple with a Seth Thomas clock. Above the steeple rests a 72 ft pierced spire; the tallest open-work spire ever built completely of stone (without reinforcement) in USA. Inside the church is a 1903 Kimball Organ, which is located in the choir loft.