Saint Joseph's Roman Catholic Church is a historic Roman Catholic church building in Mobile, Alabama, United States. It serves as the parish church for St. Joseph's Parish in the Roman Catholic Archdiocese of Mobile. St. Joseph's Parish was established in 1857. The church was designed by the architectural firm of Diboll and Owen in a Gothic Revival style. It was completed in 1907. The building was placed on the National Register of Historic Places on July 3, 1991 as part of the Historic Roman Catholic Properties in Mobile Multiple Property Submission.