Pontotoc is a city in Pontotoc County, Mississippi, United States. Pontotoc is west of the much larger city of Tupelo. It is the county seat of Pontotoc County. The famous outlaws Jesse & Frank James and their notorious gang once hid at an old house which was used as a Union Army hospital during the Battle of Harrisburg or Battle of Tupelo. The house was located at a crossroad in east Pontotoc County, near the Lee County line.