Spruce Creek is a small unincorporated community in Spruce Creek Township of Huntingdon County, Pennsylvania, United States. It was a stop on the former Pennsylvania Railroad Main Line, lying along Spruce Creek at its Confluence with the Little Juniata River. The river passes through a nearby water Gap in Tussey Mountain downstream of the village, along with the railroad line. In the eighteenth and nineteenth centuries, it was the location of a large woollen mill, but is now best known as the site of Indian Caverns which has been open to the public since 1929. Spruce Creek is also known for its World famous fly fishing. Although most of Spruce Creek is private fishing the area also holds the Little Juniata River which is open to the public. Former United States President Jimmy Carter and Pittsburgh Steelers safety Troy Polamalu have made visits to fish.