Patagonia is a town in Santa Cruz County, Arizona, United States. As of 2010 Patagonia had a population of 913. Patagonia was formerly a supply center for nearby mines and ranches. Currently, it is a tourist destination, retirement community and arts & crafts center. The Nature Conservancy's Patagonia-Sonoita Creek Preserve is adjacent to the town. Native Seeds/SEARCH also maintains an active farm for growing out and preserving seed of endangered crops in the area.
According to the United States Census Bureau, the town has a total area of 1.2 square miles (3.1 km sq), all of it land.