Nightmute is a village in Bethel Census Area, Alaska, United States. According to the United States Census Bureau, the city has a total area of 101.5 square miles (263 square kilometers), of which, 97.0 square miles (251 square kilometers) of it is land and 4.6 square miles (12 square kilometers) of it (4.50%) is water. Nightmute is also 15 to 17 miles easterly from the neighboring village of Toksook Bay. Nightmute is located on Nelson Island near Toksook Bay. The two villages connect by snowmachine trail in winter.