Mosquero is a village in Harding and San Miguel counties in the U.S. state of New Mexico. The population was 120 at the 2000 census. It is the county seat of Harding County; only a small portion of the village extends into San Miguel County. According to the United States Census Bureau, the village has a total area of 1.0 square miles (2.6 km²), all land.
As of the census of 2000, there were 120 people, 60 households, and 33 families residing in the village. The population density was 120.8 people per square mile (46.8/km²). There were 86 housing units at an average density of 86.5 per square mile (33.5/km²). The racial makeup of the village was 70.00% White, 25.83% from other races, and 4.17% from two or more races. Hispanic or Latino of any race were 77.50% of the population.