Mitchell is a city in Lawrence County, Indiana, United States. The population was 4,567 as of the 2000 census. Mitchell was built as a railroad town in the mid-19th century. At this location in Lawrence County, the Chicago, Indianapolis and Louisville Railroad, better known by the shorter name of "the Monon", was built as a north-south line from New Albany to Chicago, passing through the area which became Mitchell in 1853. In 1857, the east-west Ohio and Mississippi Railway (later part of the Baltimore and Ohio Railroad) was completed, as part of a link between Cincinnati and St. Louis. It is the birthplace of astronaut Gus Grissom, who flew on Liberty Bell 7, Gemini 3, and died in a launch pad fire at Kennedy Space Center in 1967.