Metlakatla is a census-designated place (CDP) on Annette Island in Prince of Wales-Hyder Census Area, Alaska, United States. At the 2000 census the population was 1,375.
Metlakatla comes from Maxłakxaała, a Tsimshian word meaning "Salt Water Passage." Metlakatla was named after another village of the same name ("Old Metlakatla") in British Columbia, which is on Metlakatla Pass, near Prince Rupert. In a more ancient time, it was a Tlingit hunting ground known as "Taquan". The Tsimshians were granted permission to own the land by Chief Johnson of the Tlinget tribe.