Markle is a town in Huntington and Wells Counties in the U.S. state of Indiana. The population was 1,095 at the 2010 census. It lies along Interstate 69, U.S. Route 224 and Indiana State Road 3 . As of the census of 2000, there were 1,102 people, 434 households, and 289 families residing in the town. The population density was 1,116.3 people per square mile (429.8/km²). There were 471 housing units at an average density of 477.1 per square mile (183.7/km²). The racial makeup of the town was 99.27% White, 0.36% African American, and 0.36% from two or more races. Hispanic or Latino of any race were 0.64% of the population.