Evansville is the third-largest city in the U.S. state of Indiana and the largest city in Southern Indiana. As of the 2010 census, the city had a total population of 117,429. It is the county seat of Vanderburgh County and the regional hub for both Southwestern Indiana and the Illinois-Indiana-Kentucky Tri-State Area. In 2008 a population estimate put the Evansville Metropolitan Statistical Area at 350,261. Settled in 1812, the city is situated on a gentle horseshoe bend on the Ohio River and often referred to as "River City." One of the most popular attractions in the region is Casino Aztar, the first riverboat casino in the state of Indiana. Evansville is also home to both the University of Evansville and the University of Southern Indiana.