Besides providing access to some of the most popular hiking routes in the monument, the Escalante River trailhead is located in close proximity to displays of pictographs, petroglyphs, and Anasazi ruins. The One-Hundred-Hand Panel is one of the monument's largest and most well-known pictograph panels.
The best way to view the One-Hundred-Hand Panel is probably from the Boynton Overlook. The Boynton Overlook is located on Highway 12 about a mile and a half toward Escalante from the Escalante River Crossing. Binoculars are needed to spot the panel, which is located on a set of cliffs above the Escalante River Trailhead. It is possible to hike up to the pictographs from the Escalante River Trailhead, but be careful not to cross the fence near the trailhead as this is private property.
Once the pictograph panel is found, a petroglyph panel is located downstream along the same set of cliffs as the pictographs. An old Anasazi ruin, "Moki House," is also found downstream from the trailhead. To reach the ruin, follow the trail about a hundred yards past the highway bridge and look for it in the canyon walls to the left.