Des Peres is a city in St. Louis County, Missouri, United States. The first inhabitants of Des Peres were the Cahokia, the Kaskaskia, the Michigamea, the Moingwena, and the Tamaora Native American tribes. The Osage Tribe lived in the area around Des Peres. The Osage were members of the Dhegiha Sioux group of tribes. This group also included the Ponca tribe, Quapaw tribe, Kansas tribe, and Omaha tribe.