Clare is a city in Clare and Isabella counties in the U.S. state of Michigan. North-south US 127 forms the eastern boundary for much of the city and has a junction with east-west US 10 on the east side of the city. US 10 connects with Midland, 33 miles 53 kilometers to the southeast, and with US 131 at Reed City, 44 miles 71 kilometers to the west. US 127 connects with Mount Pleasant, 13 miles 21 kilometers to the south, and with Harrison, 14 miles 23 kilometers to the north. M-115 has is southern terminus in downtown Clare.