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- Maryland, United States
The Big Annemessex River is a 15.4-mile-long (24.8 km) tributary of the Chesapeake Bay on the Delmarva Peninsula.It rises in Kingston, Somerset County, Maryland, and flows roughly southwest about 6 miles (10 km) in a meandering pattern, then widens into an estuary and continues about 9 miles (14 km) to the bay, near Janes Island State Park. Tributaries include Annemessex Creek, Holland Creek, Hall Creek, Muddy Creek, Colbourn Creek, Jones Creek and Daugherty Creek.
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