Acquavella Galleries is an art gallery located at 18 East 79th Street between Madison and Fifth Avenues in the Upper East Side neighborhood of Manhattan, New York City. Acquavella Galleries was founded at 598 Madison Avenue in 1921 by Nicholas Acquavella, a native of Naples who had come to the United States in 1919 and begun a private trade in Italian paintings. The gallery has since been operated by the Acquavella family. It originally specialized in works of the Italian Renaissance. Under Acquavella's leadership, the Acquavella Galleries introduced many leading American museums and collectors to Italian Renaissance and Baroque painting, and later to 19th- and 20th-century European masters.