Our Lady of Fatima Church, Karachi is part of the Roman Catholic Archdiocese of Karachi.
For to Celebrate the 75th anniversary of the founding of the Medical Mission Sisters, Archbishop Simeon Anthony Pereira of Karachi officiated at a Mass on September 30, 2000 at Our Lady of Fatima Church. The Holy Family Hospital, which is run by the Medical Mission Sisters, lies within the precincts of the parish. The parish is home to the Archdiocesan Redemptoris Mater Missionary Seminary. Fr. Luis Esquinas Pajuelo is the Rector. The parish is also home to the Our Lady of Fatima School for girls.