The Benemérita Universidad Autónoma de Puebla (BUAP) (Meritorious Autonomous University of Puebla) is the oldest and largest university in Puebla, Mexico. Founded on 15 April 1587 as Colegio del Espíritu Santo, the school was sponsored by Society of Jesus during most of the Spanish colonial era before turning into a public college in 1825 and eventually into a public university in 1937. This can be seen in many of the BUAP's Buildings in Puebla city downtwon, which were once colonial-era temples.
The flagship campus is located in the city of Puebla, although more than nine facilities are distributed across the state. Currently, it is one of the 105 institutes participating in the Alice Experiment at CERN.