The Church of Saint Clare in Vigna Clara (Italian: Santa Chiara a Vigna Clara, Latin: S. Clarae ad Vineam Claram) is a Roman Catholic titular church in Rome, built as a parish church by decree of Cardinal Clemente Micara. In 1969 Pope Paul VI granted it a titular church as a seat for Cardinals. The present Cardinal Priest of the Titulus Sancta Clarae ad Vineam Claram is Vinko Puljić.
The church is circular, and is based on the structure of the church of Santo Stefano Rotondo. Behind the altar is a series of paintings, which include scenes of the Nativity and the Annunciation, all done by Mariano Villalta.