San Nicola in Carcere (Italian, "St Nicholas in prison") is a titular church in Rome near the Forum Boarium in rione Ripa. It is one of the traditional stational churches of Lent. The first church on the site was probably built in the 6th century, and a 10th-century inscription may be seen on a fluted column next to the entrance, but the first definite dedication is from a plaque on the church dating to 1128.
The church is known for celebrations to the devotion of the Madonna; one is the Italian Our Lady of Pompeii (whose feast is celebrated here) and the other is the Mexican Our Lady of Guadalupe (a reproduction of whose miraculous painting, sent here from Mexico in 1773, is shown). Beneath the high altar is also an ancient basalt bath tub containing martyrs' relics.