Nostra Signora del Sacro Cuore ("Our Lady of the Sacred Heart", also known as San Giacomo degli Spagnoli) is a Catholic church dedicated to the Virgin Mary located in Rome's Piazza Navona.
The altarpiece of the Assumption of the Virgin with Glory of Angels and Apostles was made by Flemish-born painter Francisco de Castello. Most of the works of art and funerary monuments in the church were transferred to Santa Maria in Monserrato. What remains in the church are some Renaissance works, such as a chancel in polychrome marble and the marble backdrop behind the high altar. The Cappella di San Giacomo is also intact. Some of the paintings of the Herrera Chapel were transferred to Museu Nacional d'Art de Catalunya in Barcelona and some to Museo del Prado.