Santa Cruz del Quiché is a city in Guatemala. It serves as the capital of El Quiché department and the municipal seat of Santa Cruz del Quiché municipality.The city is located at an elevation of 2,021 m (6,631 feet) above sea level.
Santa Cruz del Quiché was founded by Pedro de Alvarado, a companion and second in-command of conquistador Hernán Cortés, after he burned down the nearby Maya capital city of Q'umarkaj. The oldest buildings, including a large cathedral and clock tower in the central plaza, were constructed out of the stones of the Q'umarkaj ruins by the Dominicans. Some think it likely that it was in Santa Cruz where a group of anonymous K'iche' nobles of the Nim Ch'okoj class transcribed the Popol Vuh, the sacred text of the Maya.