Nuussuaq Peninsula is a large peninsula in western Greenland. The waters around the peninsula are that of Baffin Bay. To the south and southwest the peninsula is bounded by Disko Bay, an inlet of Baffin Bay. It is separated from Qeqertarsuaq Island by Sullorsuaq Strait which connects Disko Bay with Baffin Bay. To the northeast, it is bounded by the Uummannaq Fjord system. The peninsula is mountainous, with the highest summit reaching 2,144 m.
The spinal range splits in two to the northwest of the base of the peninsula, with the southern arm forming the coastal range, the central arm almost entirely glaciated, and continuing northwest the entire length of the peninsula. The two arms are dissected by a deep Kuussuaq Valley, partially filled in the center with Sarqap Tassersuaq, a glacial, emerald lake.