The Wilhelmstraße in the Berliner district of Spandau is the connecting street between Spandau and Potsdam. In the north, at Seeburger Straße and the Ziegelhof, the Wilhelmstraße runs into the Klosterstraße, about a kilometre south of Spandau Station. It crosses the Heerstraße and from there on southwards it is also the Bundesstraße 2. At its southern end, at the „Seeburger Zipfel“ at Karolinenhöhe the Wilhelmstraße runs into the Potsdamer Chaussee.
In honour of Emperor William I's 100th Birthday in 1897, the Potsdamer Chaussee was renamed north of Karolinenhöhe into „Wilhelmstraße“. The Wilhelmstadt also got its name around this time. Before the Wilhelmstadt was called „Potsdamer“ or also „Pichelsdorfer Vorstadt“.