The Sophienkirche is a Protestant church in the Spandauer Vorstadt part of the Berlin-Mitte region of Berlin, eastern Germany. One of its associated cemeteries is the Friedhof II der Sophiengemeinde Berlin.
Designed by Philipp Gerlach, its foundation stone was laid by Frederick I of Prussia. After the death of her husband Frederick's third wife Sophie Luise von Mecklenburg-Schwerin (1685-1735), did not (as originally intended) have the church named after her at the consecration ceremony presided over by Frederick's successor Frederick William I on 25 February 1713. On 18 June 1713 the church was dedicated as the Spandauische Kirche. It was first named after Sophie Luise under his successor Frederick II, and has been called the Sophienkirche ever since.