Manchester Oxford Road Railway Station is a railway station in the city of Manchester, England. The station is located at the junction of Whitworth Street West and Oxford Street. It is Manchester's third busiest train station after Piccadilly and Victoria.
It serves the southern part of Manchester city centre, the University Of Manchester and Manchester Metropolitan University, and is on the most-served bus route in Europe. The station has a ticket office, waiting rooms, automatic ticket gates, toilets, a buffet and a newsagent. It stands on a line from Manchester Piccadilly westwards towards Liverpool, Preston and Blackpool. Trains in the eastbound direction go beyond Piccadilly to Crewe, Leeds, Sheffield and other towns across Northern England. Notable buildings close to the station include the Palace Theatre, the Cornerhouse, Palace Hotel and the 106m 17 New Wakefield Street which overlooks the station.