Puerto Asís is a Colombian municipality in the department of the Putumayo. It is located on the West Bank of the Putumayo river, downstream from the mouth of the Guamúez River, 75 km by road to the south of (Cardinal) Mocoa. It is one of the department's largest cities with a population of nearly 70,000. Puerto Asís was founded on May 3, 1912 by Capuchins Missionaries, father Estanislao de las Cortes and brother Hidelfonso de Tulcán. The city bears the name of Saint Francis's birthplace Assisi in Italy.
In order to reaffirm the sovereignty of Colombia in these territories that were contested by Peru, the government installed special programs in the region which contributed to the town's growth.