The Centro Cultural Gabriela Mistral is a cultural center located on 227 Alameda Avenue, in Santiago de Chile. The complex was originally built to serve as the headquarters for the third UNCTAD conference, which was held in Santiago in 1972, and consisted of a convention center and an adjoining 22-stories building. After the conference, the building was used as a cultural center until the 1973 Chilean coup d'état. After the end of the Pinochet regime, it hosted a number of conventions and the adjacent tower became the main building for the Ministry of National Defense.
The complex was damaged by a fire in 2006 and later remodeled to serve as a cultural center. The Centro Cultural Gabriela Mistral was inaugurated in September 2010 and is named after Gabriela Mistral.