Southern Cross is a major railway station and transport hub in Melbourne Docklands, Victoria, Australia. It is located on Spencer Street between Collins and La Trobe Streets at the western edge of the central business district. The Etihad Stadium sporting arena is 500 metres north-west of the station.
The station is the terminus of the state's regional railway network operated by V/Line, The Overland rail service to Adelaide, and the Countrylink XPT service to Sydney. It is one of five stations on the City Loop, a mostly underground railway that encircles the CBD. Based upon suburban passenger boardings it is the third busiest railway station in Melbourne, in 2009 the average was 42,900 per day. These figures exclude V/Line passengers that also use the station.