Posadas is the capital city of the Argentine province of Misiones, located at the south of the province, on the left-hand (western) shore of the Paraná River, opposite Encarnación, Paraguay. The city has an area of 965 km² and a population of 324,756 (2010 census [INDEC]), and a population of over 351,000 for the Great Posadas (2010 census [INDEC]).
Posadas is the provincial centre of the government, culture and economy. Furniture, tobacco, food, textile, and construction are its most important industries. Other important economical activities are the commerce and services.
Posadas is connected to the Paraguayan city of Encarnación by the San Roque González de Santa Cruz Bridge. The port, once of great economical importance, is used for sport vessels, carrier of passengers and some boats for sand transport. The city is located on National Route 12, some 1,300 kilometres from Buenos Aires. The General José de San Martín Airport (IATA: PSS, ICAO: SARP), at coordinates 27°22′S 55°58′W / 27.367°S 55.967°W / -27.367; -55.967, is 7 kilometres from the city, and serves regular flights to Buenos Aires.
Father Roque González de Santa Cruz established a town called Anunciación de Itapúa on March 25, 1615, but ten years later the settlement was moved to the other side of the Paraná River to the present location of Encarnación, Paraguay.