Isidro Casanova is a city in La Matanza Partido, Greater Buenos Aires, Argentina. It borders the towns of Villa Luzuriaga, San Justo, Ciudad Evita, Rafael Castillo, Laferrere, and Ezeiza.
The settlement's first significant manufacturing establishment was inaugurated shortly afterward by Isidro Casanova, an Italian Argentine immigrant. The town was renamed in his honor following his death, and one of its main streets would later be named República de Portugal in honor of the town's distinction as the home of the largest Portuguese community in Argentina. The Provincial Legislature recognized Isidro Casanova as a city on August 29, 1974. Local historian Alejandro Enrique published two volumes on the history of Isidro Casanova in 2010.