Cantwell was a railway flag stop at the junction with the Denali Highway. The original town is off the Parks Highway. It is a census-designated place (CDP) in Denali Borough, Alaska, United States. There are 178 housing units at an average density of 1.5/sq mi (0.6/square kilometers). The racial makeup of the CDP is 65.32% White, 0.45% Black or African American, 22.52% Native American, 1.80% Asian, 0.90% from other races, and 9.01% from two or more races.