Domodossola railway station serves the city and comune of Domodossola, in the Piedmont region, northwestern Italy. Opened in 1888, it forms a major break of gauge junction between standard gauge lines to Milan, Brig and Novara, and a metre gauge line to Locarno.
The station is currently managed by Rete Ferroviaria Italiana (RFI). However, the commercial area of the passenger building is managed by Centostazioni. Train services on the lines to Milan and Novara are operated by Trenitalia. Each of these companies is a subsidiary of Ferrovie dello Stato (FS), Italy's state-owned rail company.
Train services on the line to Brig are operated by the Swiss Federal Railways (SBB-CFF-FFS), and those on the line to Locarno by the Società Subalpina Imprese Ferroviarie (SSIF). These two lines combine to form an international link, via Domodossola, between the German and Italian speaking parts of Switzerland.
The passenger building has a significant architectural façcde, with a string course of Baveno granite and three cornices.