Central Macedonia is one of the thirteen regions of Greece, consisting of the central part of the region of Macedonia. With a population of over 1.8 million, it is the second most populous in Greece after Attica. The region was established in the 1987 administrative reform. With the 2010 Kallikratis plan, its powers and authority were redefined and extended. Along with East Macedonia and Thrace, it is supervised by the Decentralized Administration of Macedonia and Thrace which is based in Thessaloniki. .
Although geographically part of central Macedonia, Mount Athos is not administratively part of the region, but an autonomous self-governing state under the sovereignty of Greece. The region's governor is, since 1 January 2011, Panagiotis Psomiadis, who was elected in the November 2010 local administration elections for the New Democracy party.